Predicting longevity pathways in C.elegance

Predicting longevity pathways in C.elegance


Job Description

Predicting longevity pathways in C.elegance

Using already known genes, pathways proteins and other interactions relevant for the regulation of lifespan in C.elegence such as (non exhaustive list):

1. insulinlike signaling (IIS)
2. AMPK/mTOR signaling
3. caloric-restriction pathways (including AMPK/mTOR nutrient sensing, but also many other components)
4. Jnk-MAPK
5. p38-MAPK
7. Autophagy
8. Ubiquitin-Proteasomes
9. Mitochondrial ETC and OxPhos regulation
10. Lipid biosynthesis (FA desaturases and elongases)
11. Innate immunity & inflammation pathways
12. Adaptive immunity (but not in invertebrates)
13. TGF-beta signaling
14. p66shk
15. redox signaling
16. voltage-gated ion channels
17. proteostasis (protein folding, chaperones etc.)
18. branched-chain amino acids
19. heat-shock pathways (HSPs, HIF, etc.)
20. O-GlcNAc cycling
21. Unfolded protein response
22. Regulation of protein translation
23. xenobiotic and endobiotic detoxification

predict other genes / pathways / proteins or interactions of these that could be involved in lifespan regulation in C.elegance. Such computational predictions are intended for verification in wet-lab.

For further information please contact

Thomas Hahn
Cell phone: 318 243 3940
Skype ID: tfh002

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